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Pancreatic Stem Cells

Patient-specific hiPSCs Helps to Decipher Diabetes-related Condition

hiPSC study suggests that a loss-of-function HNF4A mutation impacts human foregut development through the perturbation of normal transcription factor function

Regenerative Potential of Pancreatic MSC Secretome

Mesenchymal stem cells (MSC) have been subcultured from various tissue, leading to a spectrum of MSCs displaying properties reflective of tissue microenvironment or developmental origin. As a result, MSCs possess a diverse range of therapeutic effects, including immunomodulatory, angiogenic, and tissue regenerative properties.

Proteomic Profiling of hPSC-derived Pancreatic Progenitors

Researchers led by Adrian Kee Keong Teo (A*STAR, Singapore) and

Direct Isolation of Human Pancreatic Progenitors

A new study reported in STEM CELLS Translational Medicine from the laboratory of

SIRT1 Promotes Beta-cell Regeneration

As calorie restriction can induce β cell regeneration, researchers led by Po Sing Leung (Chinese University of Hong Kong, Shatin, New Territories, Hong Kong) recently evaluated a role for sirtuin 1 (SIRT1), a calorie restriction mimic, in the stimulation of β‐cell regeneration. Writing in STEM CELLS, Wu et al.

Beta-cell Dedifferentiation in Type 2 Diabetes

 A recent STEM CELLS review from Shimon Efrat (Tel Aviv University, Israel) evaluated the evidence for pancreatic β‐cell dedifferentiation in type 2 diabetes and also considered the experimental systems that

The Developing Pancreas Uses the Force to Choose Between Lineages!

A study finds that integrin-ECM interactions alter intracellular forces and drives transcriptional changes that control pancreatic progenitor differentiation

NGN3-Mediated Progenitor Purification for Pancreatic Cell Differentiation

Targeting the NGN3 gene has allowed for the purification and analysis of a putative pancreatic progenitor and the analysis of its capability to produce endocrine cell progeny.

Breakthrough Discovery for Diabetes

The exciting discovery of a new, naturally occurring hormone that induces dramatic reproduction of insulin-producing beta pancreatic cells, published in the April edition of Cell by Harvard’s Douglas Melton and Peng Yi,1 has the potential to revolutionise the way that Type 2 diabetes is treated.

CD24: a Novel Surface Marker for PDX1-Positive Pancreatic Progenitors Derived from Human Embryonic Stem Cells

From the April 2011 Issue of Stem Cells

Paper Commentary by Stuart P. Atkinson

Pancreatic beta cell replacement for the treatment of type I diabetes mellitus through the directed differentiation of human embryonic stem cells (hESCs) is one of the great hopes for regenerative medicine. Great strides have been made towards this goal, although the efficient production of functionally mature functional beta cells from hESC-pancreatic progenitor cells has not yet been reported. One of the main limitations is the heterogeneity of differentiating hESC cultures in vitro. Now the group of Hongkui Deng at the School of Life Sciences at Peking University have demonstrated the potential usefulness of the cell surface marker CD24 for identification and enrichment of pancreatic progenitor cells derived from ESC. The study (Jiang et al.), published in the April Edition of Stem Cells, also shows the equivalence of in vitro differentiated pancreatic progenitor cells with those seen in vivo through the analysis of CD24 positive cells.

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