From Stem Cells
By Stuart P. Atkinson
Amongst the factors that are know to maintain pluripotent cell types, factors in the FGF pathway are perhaps the most important, as they have been implicated in cell survival, proliferation, pluripotency, and lineage determination during differentiation (Eisellova et al, Lanner and Rossant, Levenstein et al, Vallier et al and Xu et al). FGF2 is most commonly used to maintain self-renewal and pluripotency of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) (Akopian et al). However, there are several unknowns, such as the mechanisms behind FGF2 function and why high concentrations of FGF2 are required, questions which have been addressed in a study from the laboratory of James A. Thomson at the University of Wisconsin, USA (Chen and Gulbranson et al (2012)).