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ZnT3 Maintains Adult Hippocampal Neurogenesis

Researchers led by Sang Won Suh (Hallym University, Chuncheon, South Korea) recently evaluated the hypothesis that the Zinc transporter 3 (ZnT3) protein and vesicular zinc serve a critical role in the regulation of adult hippocampal neurogenesis. Reporting recently in STEM CELLS, Choi et al. now demonstrate that ZnT3-null mice display reduced hippocampal neurogenesis under physiological conditions, even at three months of age. These findings provide evidence for a central function of ZnT3 in maintaining adult hippocampal neurogenesis and for the beneficial effect of zinc supplementation on hippocampal neurogenesis, which may represent a means to enhance neuroprotection and repair after injury.