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Zbtb46 Induces ESC-derived Hematopoietic Progenitors

While the transcription factor Zbtb46 is a hallmark of dendritic cells, the exact function of this protein remains poorly characterized. In a new STEM CELLS article, researchers led by Istvan Szatmari (University of Debrecen, Hungary) probed the function of Zbtb46 in embryonic stem cell (ESC)-derived blood cell progenitors using chemically inducible transgenic cell lines. Boto et al. discovered that the forced expression of Zbtb46 profoundly suppressed myeloid blood cell development but enhanced erythroid colony formation and adult hemoglobin expression. These findings suggest that Zbtb46 can function as a molecular regulator to redirect early blood cell differentiation.