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Yap Isoforms Control ESC Self‐renewal and Differentiation

In a new STEM CELLS article, researchers led by Jiaxiang Xiong and Rui Jian (Army Medical University, Chongqing, China) report on the expression and overlapping but distinct functions of two Yap isoforms in embryonic stem cells (ESCs). Overall, Wang et al. describe the multifaceted and cell state‐dependent role of Yap isoforms in ESC fate decisions.