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Wntless Deletion in Aging Bone Marrow Stem Cells

Mechanisms by which osteoblastic Wntless deletion regulates the fate and functions of bone marrow-resident mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) in relation to age remain incompletely understood. Now, a STEM CELLS article from the lab of Jeong‐Chae Lee (Jeonbuk National University, Jeonju, South Korea) describes how osteoblastic Wls deletion impairs the bone marrow microenvironment and bone mass accrual while also inducing age‐independent senescence of MSCs in a mouse model. However, Poudel et al. also discovered that osteoblastic Wls ablation induces senescence of HSCs with the impaired production of progeny and hematopoietic development only at advanced ages.