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What’s the Stem Cells Buzz this Week? - Stem Cell-Derived EVs, Photoreceptor Neuritogenesis, Diabetic Dogs for Translational Research, and Skeletal Muscle MSC Delivery!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Proteome of Mesenchymal Stem Cell-Derived Extracellular Vesicles from Metabolic Syndrome Pigs

Researchers from the lab of Lilach O. Lerman (Mayo Clinic, Minnesota, USA) recently sought to discover if cardiovascular risk factors transformed the protein content of extracellular vesicles (EVs) released from mesenchymal stem cells (MSCs). Interestingly, Eirin et al. report that MSC-EVs derived from pigs with metabolic syndrome carried a more pro‐inflammatory signature than control pigs and hypothesized that this change might impair damaged tissue regeneration. The authors hope that their findings, reported in STEM CELLS Translational Medicine will support the development of strategies to improve the therapeutic potential of MSCs and MSC-EVs in both healthy and metabolic syndrome patients.

 

Studying Donated Photoreceptor Neuritogenesis

Recent research from the labs of Philip EB Nickerson and Valerie Wallace (University Health Network, Toronto, Canada) focused on investigating the effect of the host retinal environment on donor photoreceptor neurite outgrowth. Interestingly, Tsai et al. report novel roles for Crx, Müller glia, and Rho/ROCK signalling in controlling neurite outgrowth and provide an accessible in vitro model for the screening of factors that regulate donor‐host connectivity. The authors of this new STEM CELLS study hope that their findings will aid future work aiming to enhance the connectivity of transplanted photoreceptors.

Reviewing the Application of Diabetic Dogs for Translational Research

A new review article from the laboratory of Amir Kol (University of California, Davis, USA) outlines the therapeutic approaches and animal models employed and considers the overall value of canine diabetes mellitus (DM) as a translational animal/disease model for type 1 diabetes (T1D) in human patients. Moshref et al. highlight canine pancreatic islet physiology, comparative pathology of T1D and spontaneous canine DM, regenerative medicine approaches to treat T1D, the current state of regenerative medicine research in dogs, significant challenges in T1D‐specific regenerative medicine translational research, future perspectives, and more (phew)! Head over to STEM CELLS Translational Medicine now for all the info!

Skeletal Muscle for Mesenchymal Stem Cell Delivery

Our second review article this week from the labs of Shiva Hamidian Jahromi and John E. Davies (University of Toronto, Toronto, Canada) summarizes current thinking regarding intramuscular (IM) delivery of mesenchymal stem cells (MSCs) and the potential advantage of this site to treatment regimes. Overall, the authors highlight skeletal muscle injections as a safe means to promote prolonged dwell time in the body (when compared to the few days observed with intravenous injection) and enhance secretory output. The authors of this new STEM CELLS Translational Medicine article aim to provide a brief overview of the fate and efficacy of IM‐delivered MSCs and to identify the gaps that require further assessment for the adoption of this promising route in the treatment of systemic disease.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!