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What’s the Stem Cells Buzz this Week? - Retinal Organoids, iPSC-derived MSCs, Kit Expression, and Testicular Injury Treatment!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Single cell RNA‐Sequencing of hESC-derived Retinal Organoids

A STEM CELLS study out of the lab of Majlinda Lako (Newcastle University, Newcastle upon Tyne, United Kingdom) recently applied single-cell sequencing technologies to analyze retinal organoids generated from human embryonic stem cells (hESCs). In their new study, Collin et al. report on the sequential emergence of multiple retinal cell types during the differentiation time course, and highlight their method as an exciting means to identify multiple cell types arising within complex organoids, enabling detailed molecular and temporal systematic studies and close comparisons between in vitro derived tissues and in vivo organogenesis.

Reviewing Human Pluripotent Cell-derived Mesenchymal Stem Cells

While the application of mesenchymal stem cells (MSCs) as a treatment option for a range of diseases and disorders grows with each passing day, problems related to their supply, purity, and homogeneity remain. Do MSCs derived from pluripotent stem cells (PSCs) represent the way forward? In a new STEM CELLS review, researchers from the labs of Ren‐He Xu (University of Macau, Taipa, Macau, China) and Yingcui Li (University of Hartford, West Hartford, Connecticut, USA) now summarize the progress on PSC-derived MSCs and discusses perspectives and challenges for their potential translation to the clinic.

Kit Growth Factor Receptor in Embryo and Embryonic Stem Cell Development

In the hope of dissecting the role of the Kit growth factor receptor in pluripotency, researchers led by Susanna Dolci (Università degli Studi di Roma Tor Vergata, Rome, Italy) assessed expression levels during mouse embryogenesis and the process of embryonic stem cell derivation. Todaro et al. demonstrate that Kit expression commences in the morula stage and is maintained in the cells of the inner cell mass (ICM), with Kit levels increasing further under ground state culture conditions. Furthermore, the team discovered that Sox2 controls Kit expression in ESCs and that Kit might regulate ESC proliferation. Discover all the details at STEM CELLS now!

Administration of Stromal Vascular Fraction Attenuates Testicular Injury

Torsion‐detorsion‐induced testicular injury can impair male fertility, and a recent study has underlined the potential for stem cell-based treatments that can attenuate testicular injury and promote spermatogenesis. In their STEM CELLS Translational Medicine article, researchers from the lab of Ruipeng Jia (Nanjing Medical University, Nanjing, Jiangsu, PR China) establish that autologous uncultured adipose‐derived stromal vascular fraction (SVF) cells can protect the testis from testicular injury and promote spermatogenesis in model rats with a torsion‐detorsion‐induced testicular injury.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!