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What’s the Stem Cells Buzz this Week? - Priming MSCs, Stressing CESCs, Modeling Cardiac Disease, and Regenerating the Kidney!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Nitric Oxide-primed Mesenchymal Stem Cells Boost Engraftment

The ex vivo manipulation of hematopoietic stem cells (HSCs) to improve their engraftment ability generally employs bone marrow‐derived mesenchymal stem cells (MSCs) as a feeder cell layer. Recent research from the group of Vaijayanti Kale (National Centre for Cell Science, Pune, India) highlighted the influencing role of AKT signaling in MSCs on HSC functionality. Now, the team returns with a new STEM CELLS study, where they demonstrate that the nitric oxide primed MSCs significantly boost engraftment of HSCs via intercellular transfer of microvesicles harboring mRNAs encoding HSC‐supportive genes. Jalnapurkar et al. hope that their findings will soon help to improve transplantation efficacy in human patients suffering from a range of disorders.

Inflammation and Hyperosmotic Stress on Corneal Epithelial Stem Cells

A recent study from the laboratory of Qingjun Zhou (Shandong Academy of Medical Sciences, Qingdao, China) investigated the effects of inflammation and hyperosmotic stress on corneal epithelial stem cells (CESCs) and corneal epithelial wound healing. Yang et al. report that compared with an IL‐1β or TNF‐α induced inflammatory environment, hyperosmotic stress caused persistent impairment on corneal epithelial stem/progenitor cells by inducing more severe cell apoptosis, necrosis, and G2/M ‐arrest of the cell cycle, thereby causing more serious epithelial wound healing delay. See STEM CELLS Translational Medicine now to discover how these findings provide the cellular basis for the strict control of inflammation and dry eye before clinical limbal stem cell transplantation.

Reviewing Human in vitro Cardiac Disease Modeling

The generation and directed differentiation of human induced pluripotent stem cells (hiPSCs) have provided a means for obtaining virtually unlimited amounts of patient‐derived cardiomyocytes, while major advances in gene editing techniques have enabled the targeted mutation of specific genes, which could result in the introduction of aberrant or restored gene function. A review from the group of Peter van der Meer (University Medical Center Groningen, Groningen, Netherlands) now highlights the impact and applications of these state‐of‐the‐art techniques in the field of heart failure. See STEM CELLS Translational Medicine now for an update on this new era of in vitro cardiac disease modeling.

Reviewing Stem Cell-mediated Approaches For Kidney Regeneration

A fascinating new review article from Laura Perin (Children's Hospital Los Angeles, California, USA) discusses stem cell products as potential therapies for kidney diseases, with a firm focus on apparent discrepancies in the literature that contribute to difficulty in translating renal regenerative therapies. Marcheque et al. propose that harmonized rigorous protocols for characterization, handling, and delivery of stem cells could significantly advance the field and present details of suggested approaches to foster translation in the field of renal regeneration. See STEM CELLS Translational Medicine to read more on how the coordination of methodologies (standardization) and long‐lasting collaborations to improve protocols and models will lead to reproducible, interpretable, high‐quality preclinical data.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!