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What’s the Stem Cells Buzz this Week? - MSCs in Multiple Sclerosis, Unproven Stem Cell Interventions, ASCs in Endotoxemia, and Collagen-mediated Immune Dysfunction!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Mesenchymal Stem Cell Antioxidant Responses in Multiple Sclerosis

A previous study from the lab of Claire M. Rice (University of Bristol, United Kingdom) highlighted the reduced neuroprotective potential of mesenchymal stem cells (MSCs) derived from multiple sclerosis (MS) patients. Now, Redondo et al. demonstrate that MS-MSCs display increased susceptibility to nitrosative stress and reduced expression, activity, and secretion of critical antioxidants. The authors hope that returning the dysregulated antioxidant responses to those displayed by healthy MSCs may return the lost neuroprotective potential; see STEM CELLS Translational Medicine to discover more.

The Use of Unproven Stem Cell Interventions

A new review article from the lab of Mohamed Abou‐El‐Enein (BCRT, Berlin, Germany) recently set out to compile scientific publications, clinical case reports, and mass media publications to assess reported cases and safety incidents associated with unproven stem cell interventions (SCI). Bauer et al. hope that their efforts will help to shed new light on the magnitude and pervasiveness of such critical situations, which may pose a serious risk to vulnerable patient populations and also dilute the value of ethical and legitimate therapies currently being developed for patients through rigorous preclinical and clinical testing. For a fascinating insight into this area, head over to STEM CELLS Translational Medicine now!

Adipose-derived Stem Cells in Human Endotoxemia

To explore the application of adipose-derived mesenchymal stem cells (ASCs) in the treatment of sepsis, researchers led by Desirée Perlee (Academic Medical Center, Amsterdam, The Netherlands) assessed responses of healthy patients to ASC infusions following injections of lipopolysaccharide (LPS). This new study established the tolerability of ASC infusion and demonstrated time-dependent proinflammatory and anti-inflammatory effects and mild procoagulant features in the high-dose cohort. For all the details, see STEM CELLS now!

Collagen-mediated Immune Dysfunction

To study the impact of the trabecular extracellular matrix (ECM) of the bone marrow on hematopoiesis, researchers from the lab of Bent Brachvogel (University of Cologne, Germany) assessed the consequences of collagen IX alpha1 knockout in model mice. Probst et al. discovered that the loss of collagen IX alpha1 destabilized the trabecular bone network, impaired myeloid cell differentiation, and affected the innate immune response when challenged with Listeria moncytogenes. See STEM CELLS now for all the fine print.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!