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What’s the Stem Cells Buzz this Week? - MSC Therapy for BD, Wnt Signaling in Skin Development and Epidermal SCs, miRNAs Inhibit HSC Formation, and an In Vivo Osteogenesis Showdown!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

MSC Therapy in Bronchopulmonary Dysplasia

Extreme premature birth in children often leads to bronchopulmonary dysplasia (BPD), and while animal models suggest that mesenchymal stromal cell (MSC) therapy can protect the lungs, there are no systematic reviews or meta-analysis of the preclinical evidence……until now! Researchers from the lab of Bernard Thébaud (Ottawa Hospital Research Institute, Ontario, Canada) have crunched the numbers and have discovered that MSCs significantly improved alveolarization and ameliorated pulmonary hypertension, lung inflammation, fibrosis, angiogenesis, and apoptosis, irrespective of the timing of treatment, source, dose, or route of administration. However, the study highlights methodological shortcomings and the need to implement adequate reporting standards. See STEM CELLS Translational Medicine now for all the details.

How Wnt Signaling Controls Skin Development and Epidermal Stem Cells

A new review article from the laboratory of Wen-Hui Lien (Université Catholique de Louvain, Brussels, Belgium) hopes to provide us all with a concise summary of current knowledge on Wnt signaling pathways in the regulation of skin development, hair follicle morphogenesis, and governance of epidermal stem cells during tissue homeostasis. Furthermore, the authors also discuss the potential crosstalk of Wnt signaling with other pathways involved in these processes. See STEM CELLS now for a skin-tingling read!

microRNAs Inhibit HSC Differentiation from PSCs

The low engraftment of hematopoietic stem cells (HSCs) derived from pluripotent stem cells (PSCs) limits their therapeutic application; but just what is holding them back? Research from the laboratory of Majlinda Lako (Newcastle University, UK) posits that the expression of a distinct pattern of microRNAs prevents, at least in part, the full functionality of PSC-HSCs. The microRNA expression alterations observed promote epithelial-mesenchymal transition (EMT) and metastasis and the acquisition of an adherent phenotype in vitro. See all the fine print over at STEM CELLS.

In vivo Osteogenesis Showdown: Adipose MSCs vs. Bone Marrow MSCs

A new STEM CELLS Translational Medicine articlefrom the lab of Pierre Layrolle (University of Nantes, France) has brought us the results of an interesting showdown: the in vivo bone forming potential of bone marrow and adipose mesenchymal stem cells (MSCs). Brennan et al. now reveal that bone marrow MSCs hold the advantage of adipose MSCs with regards to osteogenesis and engraftment, although bone marrow MSCs exhibit lower angiogenic potential. Therefore, even though adipose MSCs represent an easily accessible and easy to cultivate cell type, bone marrow MSCs seem to have the in vivo osteogenic edge!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!