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What’s the Stem Cells Buzz this Week? - Fibrous Dysplasia Regulation, Allergic Asthma, Brain Neurogenesis, and MSC Adipo-osteogenesis!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

HDAC8 Pathway Regulates the Fibrous Phenotype Dysplasia

Bone marrow stem cells (BMSCs) in patients suffering from fibrous dysplasia (FD) display osteogenic defects, and we currently lack targeted therapeutic strategies. Researchers from the laboratory of Hongbing Jiang (Nanjing Medical University, Jiangsu Province, China) compared normal- and FD-BMSCs, discovering a significant role for the cAMP‐CREB1‐HDAC8 pathway in regulating biological characteristics of FD-BMSCs. Xiao et al. also noted that HDAC8 inhibition leads to significant therapeutic effects in an in vitro experimental model of FD and nude mice implanted with FD-BMSCs. For more, see STEM CELLS Translational Medicine now!

Therapeutic Effects of Mesenchymal Stem Cells in Allergic Asthma

New research from the lab of Patricia R.M. Rocco (Federal University of Rio de Janeiro, Brazil) recently assessed the ability of bronchoalveolar lavage fluid or serum from asthmatic mice to prime mesenchymal stem cells (MSCs) in the hope of improving their immunomodulatory properties in asthma treatment. In their new STEM CELLS Translational Medicine article, Abreu et al. used a house dust mite extract asthma mouse model to demonstrate that serum-exposed MSCs promoted the most significant reduction of inflammation and remodeling and the greatest improvement in lung function. The authors suggest that these positive findings may provide a platform for future clinical trials in patients with asthma.

Systemic Factors drive Brain Neurogenesis via Notch Ligand DLL4

New research from the lab of Lorraine Iacovitti (Thomas Jefferson University, Philadelphia, Pennsylvania, USA) recently reported that the leaky blood-brain barrier (BBB) in niches of the intact and stroke brain could respond to circulating VEGF165 to drive neural stem cell (NSC) activation and neurogenesis via the induction of the DLL4 Notch ligand in endothelial cells and pericytes. Lin et al. establish that enhanced DLL4-notch signaling and crosstalk between vasculature cells and NSCs regulates the activities of NSCs when triggered by systemic stroke-induced factors. For more details, see STEM CELLS now!

Smad4-Taz axis in Adipo-osteogenesis of Mesenchymal Stem Cells

In a new study assessing the factors that promote the differentiation of mesenchymal stem cells (MSCs), researchers from the laboratory of Seok Hee Park (Sungkyunkwan University, Suwon, South Korea) have highlighted the importance of the Smad4‐Taz axis in adipo‐osteogenesis. In their new study, Park et al. demonstrated that Smad4 plays a crucial role in the regulation of lineage commitment of MSCs, including human adipose tissue-derived stem cells (hASCs), into osteoblasts and adipocytes through modulating the retention of TAZ in the nucleus during MSC differentiation. Discover more at STEM CELLS now!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!