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What’s the Stem Cells Buzz this Week? - Distal Limb Wound Healing, Dentin-Pulp Tissue Regeneration, Report from the ISCBI, and MSCs Requirement for Survivin!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

MSC-mediated Healing of Distal Limb Wounds

Both humans and horses may benefit from allogeneic mesenchymal stem cell (MSC) therapy for distal extremity wounds. To assess the potential benefits of this treatment option, researchers from the laboratory of Dori L. Borjesson (UC Davis, California, USA) assessed gross, histologic, and transcriptional features of healing in a horse model. Encouragingly, Textor et al. discovered that direct injection of MSCs into the wound margin correlated to smaller wound area and improved histologic outcomes and the authors hope that their finding may be directly applicable to chronic wound studies in human patients. Stop horsing around and head over to STEM CELLS Translational Medicine for more details.

PDGF-BB Boosts Stem Cell-Based Dentin-Pulp Tissue Regeneration

An exciting new study in STEM CELLS Translational Medicine from Xinquan Jiang and Wenjie Zhang (Shanghai Jiao Tong University, PR China) sought to delineate how platelet-derived growth factor (PDGF) promotes dental pulp stem cell (DPSC)-mediated dentin-pulp complex regeneration. Zhang et al. discovered that the PDGF-BB dimer enhanced DPSC proliferation and odontoblastic differentiation, stimulated angiogenesis, and facilitated migration via PI3K/Akt signaling pathway activation. All these enhancements permitted PDGF-BB gene-modified DPSCs to generate more dentin-like mineralized tissue surrounded by highly vascularized dental pulp-like connective tissue than unmodified DPSCs!

International Stem Cell Banking Initiative Workshop Activity Report

A recent article from Glyn N. Stacey (UK stem Cell Bank) and Soo Kyung Koo (Korea National Institute of Health) reviews recent discussions among world-leading groups working on the provision of stem cell lines for research and clinical use, which addresses the latest thinking on in issues of quality control, safety, and ethics. A key outcome from the reported workshops in the USA and Korea was the confirmation of the need for standards, and, in particular, the principles of best practice developed by the International Stem Cell Banking Initiative. For all the details, see STEM CELLS Translational Medicine now!

An Essential Role for Survivin in MSCs

A new study from the labs of Louis M. Pelus and Pratibha Singh (Indiana University, USA) demonstrates that Survivin regulates mouse and human mesenchymal stem cell (MSC) function and suggest that clinical application of Survivin may enhance MSC recovery and activity following insult or stress. In their new STEM CELLS study, Singh et al. show how MSC survival (surprise!), expansion, lineage commitment, and migration require Survivin. In vivo analysis also established that Survivin loss suppressed MSC migration to a wound site and compromised their hematopoiesis-supporting capacity.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!