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What’s the Stem Cells Buzz this Week? - Differing Stem Cell Interests, Fanconi anemia MSCs, Pro‐angiogenic Hematopoietic Cells, and a Study under Discussion!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Differing Interests in Stem Cell Research

Researchers from Ryuma Shineha (Seijo University) and Yoshimi Yashiro (Kyoto University, Japan) have recently carried out a large-scale survey with 2,160 public responses and 1,115 responses from the member of the Japanese Society for Regenerative Medicine to gauge their differing interests. The authors hope that the results of this study, published in STEM CELLS Translational Medicine, can serve to aid further communication between scientists and the public to create a common future vision.

Reduced Cdc42 Compromises Fanconi anemia MSC Function

The inherited bone marrow (BM) failure syndrome Fanconi anemia (FA) strongly affects the hematopoiesis-supportive function of BM mesenchymal stem cells (MSCs), and a recent study from the lab of Wei Du (West Virginia University, USA) recently set out to why this happens. Interestingly, FA MSCs displayed defects in proliferation and enhanced senescence, to which the authors linked a reduction in the activity of Cdc42 a Rho GTPase and critical regulator of cytoskeleton organization. See STEM CELLS now for all the details!

Expansion of Pro‐angiogenic Hematopoietic Cells

While umbilical cord blood (UCB)-derived hematopoietic progenitor cells represent a potentially interesting cell type for applications in the treatment of severe vascular diseases, ex vivo expansion of UCB leads to the loss of such cells. However, researchers from the lab of David A. Hess (Western University, London, ON, Canada) have described a possible strategy to avoid this loss. Cooper et al. report in STEM CELLS that limiting retinoic acid‐induced differentiation by the inhibition of aldehyde dehydrogenase (ALDH) activity led to the expansion of pro‐angiogenic multipotent progenitor cells with vascular regenerative function. Great news!

Article under Discussion!

A recent study in STEM CELLS from the lab Majlinda Lako (Newcastle University, UK) has come under discussion with the publication of an article from the group of Baljean Dhillon (University of Edinburgh, UK) and the reply from the original authors. For a thought-provoking back and forth regarding the experimental details and ultraviolet light as a potential therapy for age-related macular degeneration (AMD) patients, head on over to STEM CELLS.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!