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What’s the Stem Cells Buzz this Week? - Cord Blood Treatment of Autism, Enhanced Wound Healing, Reviewing Neurological Chimeras, and Senescent Cardiac Stem Cells!

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The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

White Matter and Cord Blood Treatment in Autism Spectrum Disorder

Previous research from the laboratory of Kimberly L. H. Carpenter (Duke University School of Medicine, Durham, NC, USA) highlighted the potential for autologous cord blood infusion as a treatment approach for autism spectrum disorder (ASD). Now, the team returns with a new article in which they describe how behavioral improvements following cord blood therapy associates with elevated white matter connectivity in frontal, temporal, and subcortical regions that display anatomical, connectivity, and functional abnormalities in ASD. For all the details on this encouraging new findings, see STEM CELLS Translational Medicine now!

Salidroside-Pretreated Mesenchymal Stem Cells Boosts Wound Healing

New research from the labs of Vivi Kasim and Shourong Wu (Chongqing University, PR China) sought to discover if the glucopyranoside salidroside, a known cytoprotective agent, could boost mesenchymal stem cell (MSC) survival under hyperglycemic conditions and promote wound healing in diabetic model mice. In their recent STEM CELLS Translational Medicine report, Ariyanti at al. established that salidroside treatment significantly increased MSC paracrine function, survival, antioxidant defense, and migration potential, most likely by restoring the expression levels of HO‐1, FGF2, and HGF that decreased under hyperglycemia. Encouragingly, these improvements led to enhanced wound closure and re‐epithelialization in diabetic model mice administered with pretreated MSCs.

Reviewing Human-Animal Neurological Chimeras

Ethical issues surrounding blastocyst complementation, an emerging methodology in which human stem cells are transferred into genetically engineered pre‐implantation animal embryos, have raised concerns from National Institutes of Health due to the potential of human cells to substantially contribute to the brain of chimeric animals. Now, a review article from the labs of Andrew T. Crane and Walter C. Low (University of Minnesota, Minneapolis, USA) addresses these concerns by performing an in‐depth review of the neural transplantation literature to determine how the integration of human cells into the non‐human neural circuitry alters host behavior. Overall, the authors suggest that research should proceed, but in a controlled and transparent manner; see STEM CELLS now for all the details.

Hypoxia Blunts Senescence of Cardiac Stem Cells

The recapitulation of hypoxic niche oxygen tension during the culture of cardiac progenitor cells (hCPCs) can reduce senescence, preserve self‐renewal, and provide significant improvements in functionality and biological activity. Now, a team led by Mark A. Sussman (San Diego State University, San Diego, CA, USA) reports that hypoxia preserves the clonogenicity and mitochondrial function of hCPCs derived from heart failure patients while maintaining high levels of intracellular NAD+/NADH ratio and suppressing reactive oxygen species (ROS) and oxidative stress. Korski et al. demonstrate that this reduction in ROS production then “blunts” hCPC senescence and therefore encourages their application in regenerative approaches. See STEM CELLS now to discover more.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!