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What’s the Stem Cells Buzz this Week? - Appraising iPSC Clinical Translation, Reviewing Periodontal Regeneration, Knee Osteoarthritis MSC Trial, and Changing mESC Bioenergetics!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Reviewing the Clinical Translation of Induced Pluripotent Stem Cells

A new review article out of the laboratory of Nico Lachmann (Hannover Medical School, Germany) provides a brief overview of the recent developments and challenges faced during the progression of induced pluripotent stem cell (iPSC)-derived blood cells to clinical translation. While examples of the clinical transfer of iPSC‐derived hematopoietic cells remain few, this great new article from Haake et al. describes the advances made in hematopoietic differentiation of iPSCs and provides a current perspective on GMP‐compliant cell production. See STEM CELLS Translational Medicine now to keep up to date!

Periodontal Regeneration via Stem Cell Therapy: A Concise Review

Our second review article, this time from the laboratories of Fa‐Ming Chen and Hai‐Hua Sun (Fourth Military Medical University, Xi'an, PR China) provides a summary of stem cell-based regenerative approaches used for the periodontal tissue regeneration. Xu et al. believe that research efforts should concentrate on making cell therapy and tissue engineering more practical and economical, as well as safer, in the hope of facilitating the translation of ex vivo manipulated stem cells into clinical use. For more, head over to STEM CELLS Translational Medicine.

Trialing Umbilical Cord Mesenchymal Stem Cells for Knee Osteoarthritis

Osteoarthritis, the principle musculoskeletal disorder in adults, suffers from a lack of treatments that provide more than light relief. However, a new trial led by Francisco Espinoza (Universidad de los Andes, Santiago, Chile) has now shown that umbilical cord‐derived mesenchymal stem cells (UC-MSCs) represent a safe and potentially effective means to treat knee arthritis. Given that UC-MSCs represent a highly accessible allogeneic cell source, Matas et al. believe that their regenerative potential will soon be demonstrated in larger trials, with the hope of developing this approach into a simple, scalable, cell‐based therapy open to repeated applications with no need for invasive surgical procedures. Read all the details at STEM CELLS Translational Medicine.


The Changing Bioenergetic Profiles of Differentiating Murine ESCs

A new study from researcher led by Helene Boeuf (University of Bordeaux, France) now reports their findings regarding the critical metabolic changes occurring as mouse embryonic stem cells (mESCs) pass from pluripotency to differentiation. Vlaski‐Lafarge et al. report that while self-renewing mESCs and early differentiating mESCs employ both oxidative phosphorylation and glycolysis, they soon transit to a mainly glycolytic state 48 hours after differentiation. For more details on this crucial aspect of mESC biology, look no further than STEM CELLS.

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!