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What’s the Stem Cells Buzz this Week? – BM-MSCs in Lung Injury Treatment, Fine Tuning PSC Differentiation, Immunomodulation by hiPSC-MSCs, and a Perspective on Digit Tip Regeneration!



The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Regulating BM-MSC Survival in Lung Injury Treatment

An understanding of how bone marrow-derived mesenchymal stromal cells (BM-MSCs) survive following transplantation into animal models of disease may allow us to enhance treatment strategies. Researchers from the lab of Naveen Gupta (University of California, San Diego, USA) recently demonstrated that the TLR4 and PAR1 pathways cooperate to regulate BM-MSC survival and therapeutic activity in a mouse model of bacterial pneumonia. Can we apply this information to enhance BM-MSC-based treatments for lung injuries brought on by disease? See STEM CELLS now for all the fine print.

Wnt Fine Tuning of Pluripotent Stem Cell Differentiation

Optimizing the differentiation of pluripotent stem cells into clinically relevant cell types will aid the construction of efficient and effective regenerative strategies. A recent STEM CELLS report from the labs of Christian M. Nefzger, Jose M. Polo, and Tiziano Barberi demonstrates that canonical Wnt stimulation at levels below that required for β‐catenin‐mediated TCF signaling enhances PSC differentiation into multiple cell types. This interesting phenomenon, mediated by β‐catenin/cadherin interactions at the cell membrane, reveals dual, dosage‐dependent roles for Wnt/β‐catenin stimulation in PSC differentiation.

Immunomodulatory Capacity of hiPSC-MSCs

The production of mesenchymal stem cells from induced pluripotent stem cells (iPSC-MSCs) represent an exciting patient-specific means of generating large amounts of cells for regenerative therapies. However, some studies have reported that iPSC-MSCs suffer from deficiencies in their immunomodulatory capacity. Researchers from the laboratory of B. Linju Yen (National Health Research Institutes, Zhunan, Taiwan) now report in STEM CELLS that MSCs differentiated from iPSCs reprogrammed employing diverse cell types and protocols all present with robust immunomodulation capabilities thereby supporting iPSC-MSCs as therapeutic candidates. Great news!

Perspective - Digit Tip Regeneration

A new Perspective article from the laboratory of Ken Muneoka (Texas A&M University, USA) discusses the interface of regeneration biology with regenerative medicine when considering mammalian regeneration models such as mouse digit tip regeneration. Can we promote regeneration rather than replacing damaged structures? See this thought-provoking piece now in STEM CELLS Translational Medicine for a possible answer!

That’s a wrap for now! Please feel free to leave a comment and discuss the papers covered here on the Stem Cells Buzz. Happy reading!