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In vivo Analysis of Friedreich Ataxia iPSC‐derived Neurons

Within the nervous system, dorsal root ganglia (DRG) sensory neurons sense pain, touch, muscle movement, and tension; however, DRG neurons degenerate in pathological conditions and diseases such as diabetes and Friedreich ataxia. In a new STEM CELLS Translational Medicine study, researchers led by Lachlan Thompson (University of Melbourne, Parkville) and Mirella Dottori (University of Wollongong, Wollongong, Australia) describe the transplantation of human induced pluripotent stem cell (iPSC)-derived DRG sensory neurons into the DRG tissue region of adult rodents. The results from Viventi et al. support stem cell‐based therapies to treat peripheral DRG neuropathies such as Friedreich ataxia.