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Trpv4 Regulates iPSC Chondrogenesis

Transient receptor potential vanilloid 4 (TRPV4), an osmo- and mechano- sensitive cation channel, is highly expressed in chondrocytes. Researchers led by Farshid Guilak (Washington University, St. Louis, MO, USA) recently examined the hypothesis that TRPV4 serves as a marker and a regulator of chondrogenesis in induced pluripotent stem cells (iPSCs). In their recent STEM CELLS article, Willard et al. discovered that Trpv4 expression mirrored the expression of classic chondrogenic markers during chondrogenesis; furthermore, the authors established that intermittent activation of TRPV4 significantly increased cartilaginous matrix production. Overall, an improved understanding of the role of TRPV4 in chondrogenesis may provide insight into the development of new therapeutic approaches for diseases affecting cartilage.