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Treating ETEC by Restoring Wnt‐dependent ISCs

New research led by Xiu‐qi Wang (South China Agricultural University, Guangzhou, China) suggests that the heat‐stable enterotoxins associated with enterotoxigenic Escherichia coli (ETEC) infections inhibit intestinal stem cell (ISC) expansion and disrupts the integrity of intestinal mucosa through the downregulation of Wnt/ß‐catenin signaling. Furthermore, Zhou et al. report that the activation of Wnt/ß‐catenin signaling can reverse this process. Overall, the authors provide evidence that ISC dysfunction associates with the occurrence and development of diarrhea and supports the notion of the restoration of Wnt‐dependent ISCs as a promising therapeutic target for ETEC treatment. For more, see STEM CELLS now!