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Topical Stem Cell Therapies for the Ocular Surface

A new STEM CELLS Translational Medicine review article from the lab of Laura E. Sidney (University of Nottingham, UK) focuses on the potential of engineered mesenchymal stem cell (MSC) therapies that can be topically applied to the ocular surface to treat inflammatory disorders that cannot be managed through steroids or other means. Beeken et al. highlight different considerations, including whether the source of MSC isolation may impact the efficacy and safety of the therapy, and assess the feasibility of topical stem cell application to the ocular surface through an analysis of potential scaffolds.