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TNTs Mediate Senescence in MSC Spheroids

Previous studies from the labs of J. Kent Leach and Gang‐yu Liu (University of California, Davis, USA) demonstrated the presence of actin‐rich tunneling nanotubes (TNTs) in mesenchymal stem cell (MSC) spheroids that may function to mediate cell survival via the exchange of cytoplasmic components. In their new STEM CELLS study, Whitehead et al. confirm a role for TNTs in the modulation of the senescence phenotype and establish that co‐culture with early passage MSCs can reduce the effect of senescence in late‐passage MSCs. The authors hope that their findings will allow the effective therapeutic application of late passage MSCs in autologous therapeutic strategies in elderly patients.