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TIMP Proteins Inhibit PSC-derived Teratoma Formation

The ablation of proliferative pluripotent stem cells (PSCs) before or after the transplantation of PSC-derivatives would significantly reduce associated risks, including teratoma formation. In their new study, researchers led by Sunghoi Hong (Korea University, Seoul, South Korea) report in their discovery that neural stem cell‐conditioned medium (NSC‐CM) and/or TIMP (tissue inhibitor of metalloproteinase) proteins inhibited the proliferation of PSCs and PSC‐derived neural precursor (NP) cells without influencing the potential of PSC‐NP cells to differentiate into neurons in vitro and prevented teratoma growth in vivo. For all the details on this fascinating new study from Choi et al., see STEM CELLS now!