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Targeting Cancer Stem Cells Via Lipid Metabolism

A recent STEM CELLS review article from the laboratory of Arun Dharmarajan (Curtin University, Western Australia, Australia) describes the significance of the altered lipid metabolism observed in cancer stem cells. Furthermore, the authors discuss the critical metabolic modifications occurring in cancer stem cells that enable tumorigenesis through enhanced dependence on fatty acid synthesis and β‐oxidation to fulfill their heightened energy and biomass requirements. Additionally, Visweswaran et al. summarize various anti‐cancer therapeutic strategies that target cancer stem cell lipid metabolism.