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Sustainment of Prostate Luminal Cell Lineages

A new study from the lab of Li Xin (University of Washington, Seattle, WA, USA) has characterized the phenotypic and functional heterogeneity of mouse prostate luminal epithelial cells. Reporting in STEM CELLS, Kwon et al. now describe a critical role of Sox2 in maintaining the facultative bipotent differentiation capacity of Sca‐1+ luminal cells.