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Stem Cell Therapies Affect Clotting following Trauma

While various stem cell-based therapeutics are currently under investigation as a treatment option following trauma, such as brain or lung injury, stem cells readily express tissue factor (TF), which causes rapid blood clotting. Now, new research from the laboratory of Mitchell J. George (McGovern Medical School at The University of Texas Health Science Center, Houston, Texas, USA) provides evidence for the acceleration of clot formation in trauma patients as TF load of a given stem cell treatment increases. Furthermore, the team demonstrates heparin as a potential reversal agent in response to this procoagulatory effect. For all the details, see STEM CELLS Translational Medicine now!