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Smurf2 Regulates PTX3 Stability and MSC Angiogenesis

Angiogenesis participates in the pathogenesis of ankylosing spondylitis, an inflammatory disease that can cause bone fusions in the spine. The dysregulated angiogenesis of mesenchymal stem cells (MSCs) closely associates with inflammation and disturbance of bone metabolism in various diseases. A new STEM CELLS article from researchers led by Huiyong Shen and Yanfeng Wu (Sun Yat‐sen University, Shenzhen, Guangdong, China) reports that ATF4‐induced endoplasmic reticulum stress in MSCs derived from ankylosing spondylitis patients induces SMAD‐specific E3 ubiquitin ligase 2 (Smurf2) transcription and the subsequent negative regulation of pentraxin 3 (PTX3) and the abnormal promotion of angiogenesis.