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Separase Disruption Promotes HSC Regeneration

A new STEM CELLS study led by Debananda Pati (Baylor College of Medicine, Houston, Texas, USA) reports a novel role for the cohesin protease, Separase, in hematopoiesis and hematopoietic stem cell (HSC) function. The cohesin complex has recently emerged as a critical regulator of self‐renewal and differentiation in HSCs, and cohesin genes are among the most recurrently mutated gene categories in myeloid malignancies. Kumar et al. hope their findings will bridge a critical knowledge gap and represent a significant advance in this research field.