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The Role of Tailless in Neurogenesis

In a new STEM CELLS study, researchers led by Ying Wang (Nanjing Medical University, Nanjing, China) used a novel mouse model overexpressing orphan nuclear receptor Tailless (Tlx) to demonstrate how Tlx expression modulates neurogenesis. Wang et al. discovered that Tlx bound to the promoter of Sox2 and reduced endogenous expression to inhibit neurogenesis. Overall, these findings highlight the importance of shutting off Tlx correctly in controlling neural stem cell (NSC) behavior and provide insights for a deeper understanding of adult neurogenesis and developing treatment strategies for neurological disorders.