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Reviewing Stem Cell Therapies for OA

Despite the promise of stem cell‐based therapies as a treatment option for osteoarthritis (OA), results have fallen short of expectations. Researchers led by David Hunter (University of Sydney, NSW, Australia) and Daniel Worthley (South Australian Health and Medical Research Institute, South Australia, Australia) now ask if current knowledge of the stem cell biology of articular cartilage reflects their potential in health and disease and whether we can expand on the current understanding of the promise and practice of stem cell therapy for OA. Ng et al. summarize some of the responses to these questions in a new STEM CELLS review article while also discussing the new developments in articular stem cell biology and the current clinical status of stem cell‐based therapy for OA.