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Reviewing Aged Stem Cell Restoration

Researchers led by Isabel Beerman (NIH, Baltimore, Maryland, USA) discuss the current status of interventions to improve stem cell aging phenotypes in a recent concise review article published in STEM CELLS. Spehar et al. state that the restoration of aged stem cells may lead to a beneficial cascade throughout the entire system; however, as many interventions have been reported in only a few tissue‐specific stem cell types, a more comprehensive analysis of potential benefits and consequences to all stem cells is required. The authors highlight overlaps between interventions and proposed considerations required before translating interesting approaches into human trials.