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Resistance of Neural Stem Cells to Chemo‐Radiation Therapy

Standard of care therapy for aggressive glioblastoma consists of safe maximum resection, concurrent temozolomide and X‐irradiation followed by adjuvant temozolomide therapy; however, we do not understand if this treatment approach affects adult neurogenesis in the ventricular‐subventricular zone (V‐SVZ) of the mammalian brain. Reporting in a new STEM CELLS study, researchers from the lab of Michael L. Freeman (Vanderbilt University Medical Center, Nashville, TN, USA) show that neural stem cells overexpress the anti‐apoptotic proteins Bcl2 and Mcl1 and do not undergo apoptosis in response to concurrent chemo‐radiation therapy. Overall, Cameron et al. therefore suggest that stem cell resistance will sustain neurogenesis and that targeting the V‐SVZ for the treatment of glioblastoma will not result in unacceptable toxicity.