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Reporter Gene Imaging of MSC Therapy in the Heart

Due to the increasing awareness in the cell therapy community of a need to better understand the biology of transplanted cells in the myocardium, researchers led by Martin Rodriguez‐Porcel (Mayo Clinic, Rochester, Minnesota, USA) previously reported the use of reporter gene labeling of stem cells to track cell viability kinetics. Peterson et al. extend these studies and report the development and validation of a pathway‐specific reporter gene to study the changing phenotype of mesenchymal stem cells (MSCs) after transplantation into the ischemic myocardium. In their new STEM CELLS reports, the team also proposes an algorithm for the development of these monitoring strategies for the entire scientific community to adopt.