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Regenerative Potential of Pancreatic MSC Secretome

Mesenchymal stem cells (MSC) have been subcultured from various tissue, leading to a spectrum of MSCs displaying properties reflective of tissue microenvironment or developmental origin. As a result, MSCs possess a diverse range of therapeutic effects, including immunomodulatory, angiogenic, and tissue regenerative properties. In a new STEM CELLS study, researchers led by David A. Hess (Western University, London, ON, Canada) utilized label‐free mass spectrometry and functional analyses to characterize the proteome and secretome of MSC populations established from human pancreas tissue. Cooper et al. reported that pancreatic MSCs demonstrated a unique Vimentinhigh/Nestinhigh proteome restricted from adipogenesis, yet pancreatic MSCs secreted proteomic effectors associated with endothelial cell chemotaxis, angiogenesis, and islet regeneration. Overall, the authors believe that their findings will help to fully elucidate the secretory functions of pancreatic MSCs as a possible therapeutic agent for regenerative medicine applications.