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RAS and the Embryonic Emergence of HSPCs

Self‐renewing multipotent hematopoietic stem/progenitor cells (HSPCs) are first generated inside the developing embryo as clusters of emerging cells associated with the ventral side of the aortic endothelium. A new STEM CELLS study from the laboratory of Manuela Tavian (University of Strasbourg, France) now reports that a local active renin‐angiotensin system (RAS) exists in this hemogenic site and contributes to blood generation. In summary, Angiotensin II‐signaling activates the type 1 receptor and increases the emergence of undifferentiated HSPCs inside the embryo.