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PSC-derived Liver Cells as a Disease Modeling Tool

The liver is an essential organ in the body that performs crucial functions such as metabolism, and recently, researchers have invested enormous resources to generate liver cells from induced pluripotent stem cells and to develop robust three-dimensional liver organoids that faithfully resemble the liver. Now, a team led by Setjie W. Maepa and Hlumani Ndlovu (University of Cape Town, South Africa) review in detail those advances that have been achieved towards the development of protocols to generate hepatocytes, cholangiocytes, and Kupffer cells, and discuss the application of these tools to model liver disease with a specific focus on hepatic steatosis, acute liver failure, and drug-induced liver injury. For all this, and more, see STEM CELLS now!