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Promoting Bone Defect Repair After Radiation

Radiotherapy combined with surgery to treat skeletal tumors usually leads to significant bone defects and hampers wound healing. Skeletal stem cells (SSCs) may form part of advanced bone regeneration strategies, while ferulic acid, a phytochemical with a wide range of therapeutic effects, can alleviate radiation‐induced oxidative stress and promote tissue regeneration. In a new STEM CELLS Translational Medicine study, researchers led by Heng Zhu (Beijing Institute of Radiation Medicine) and Li Ding (Air Force Medical Center, Beijing, China) report that ferulic acid alleviates radiation‐induced impairment of SSCs and promotes SSC‐mediated bone regeneration post-radiation both in vitro and in vivo.