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Proangiogenic CD146-Positive Adipose MSCs

A new STEM CELLS Translational Medicine article from the lab of Derrick C. Wan (Stanford University, Stanford, CA, USA) recently reported on the identification of an adipose‐derived mesenchymal stem cell (MSC) subpopulation that expressed the surface marker CD146 and elevated levels of proangiogenic genes and possessed an enhanced capacity to induce endothelial‐tube formation. Borrelli et al. discovered that upon transplantation, CD146-positive adipose MSCs underwent less resorption and displayed improved histologic quality and vascularization. Overall, the authors believe they have identified a subpopulation of adipose MSCs with enhanced angiogenic effects in vitro and in vivo, and that enriching lipoaspirates with CD146-positive adipose MSCs may enhance fat graft vascularization and retention in the clinical setting.