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Predicting BM-MSC Functions Using Imaging

Clinical trials employing cultured human bone marrow mesenchymal stem cells (hBM‐MSCs) have demonstrated the presence of significant inter‐donor variability in biological functions and clinical efficacy. For this reason, researchers led by Moustapha Kassem (Odense University, Denmark) applied a high‐content imaging methodology to cultured BM‐MSCs obtained from a large cohort of donors to identify morphological features, including cell area and nucleus geometry, as predictors for cell differentiation and proliferation. Kowal et al. hope that said parameters could serve as selection criteria for BM‐MSC populations to be used in clinical trials of enhancing bone regeneration. For more, see STEM CELLS Translational Medicine now!