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Preclinical MSC-Exosomes: A Review

The growing interest surrounding the therapeutic application of purified and concentrated regenerative factors secreted by mesenchymal stem cell (MSCs) has recently focused on exosomes, which are now understood to be critical active pharmaceutical ingredients of MSC‐based therapies. A recent STEM CELLS review article from the lab of Johnathon D. Anderson (University of California Davis, Sacramento, CA, USA) now summarizes the current state of preclinical development of MSC-derived exosome therapeutics parsed from over 200 peer-reviewed reports utilizing various animal models, Furthermore, the authors discuss opportunities that may be addressed that would help to strategically advance the field of MSC-derived exosome therapeutics.