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PKC‐β Modulated Metabolism in CLL BMSCs

The bystander relationship between cancer cells and bone marrow stem cells (BMSCs) leads to the pro‐survival activities of BMSC, such as the expression of stromal protein kinase C (PKC)‐β, which contributes to cancer growth and progression. Increasing amounts of evidence suggest that leukemic cells can modify neighboring cells' metabolic pathways to satisfy their energy demands. Therefore, the metabolic characterization of the tumor microenvironment might reveal novel strategies to target as an alternative to cytotoxic therapies. Researchers led by Gloria Lutzny‐Geier (Friedrich‐Alexander‐Universität Erlangen‐Nürnberg, Erlangen, Germany) now describe a link between stromal metabolism and PKCβ expression in BMSCs after contact with primary chronic lymphocytic leukemia (CLL) cells. For more, see STEM CELLS now!