You are here

Piezo1 Channel Activation Drives MSC Migration

While mesenchymal stem cells (MSC) release ATP as an extracellular signaling molecule in response to mechanical and diverse other stimuli, the underlying mechanisms remain largely unknown. However, findings reported in STEM CELLS from the laboratory of  Lin‐Hua Jiang (University of Leeds, UK) now describe how the Ca2+‐permeable Piezo1 channel, a newly‐discovered mechanosensing mechanism, regulates the migration of human dental pulp‐derived MSCs by inducing ATP release and subsequent activation of P2 receptor purinergic signaling. Mousawi et al. provide novel insights into the mechanisms regulating MSC migration in the hope that an increased understanding of MSC migration may improve the application of MSCs in tissue engineering and regenerative medicine.