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Perivascular Stem Cells Inhibit Osteoclasts

Perivascular progenitor cells exert positive regulatory effects on osteoblasts to heal bones, yet their potential role in osteoclast regulation remains relatively unknown. In a new STEM CELLS Translational Medicine study, researchers led by Aaron W. James (Johns Hopkins University, Baltimore, Maryland, USA) now report that human perivascular progenitor cells reduce osteoclast formation, thereby preventing bone graft resorption and yielding better outcomes in a preclinical xenograft model. Negri and Wang et al. anticipate the use of perivascular stem cells to augment bone grafts by serving as a pro‐anabolic, antiosteoclastic stimulus to boost outcomes in orthopedics.