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PDGFRα-Expressing Perivascular Progenitors

Researchers led by Aaron W. James (Johns Hopkins University, Baltimore, MD, USA) recently discovered that platelet‐derived growth factor-alpha (PDGFRα) expression marks perivascular subpopulations of adipose stroma that possess a heightened tendency to take part in osteoblastogenesis. As a possible pathologic correlate of these observations, Wang et al. report the possible involvement of progenitor cells found in the tunica adventitia (the outermost layer of a blood vessel) in arteriosclerosis by supplying the remodeling vessel with calcifying cells. Can a strongly osteogenic PDGFRα‐expressing subset of adventitial progenitor cells become a therapeutic target? See STEM CELLS now to find out.