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PAX6-targeted miRNA in Human Retinal Organoids

In a new STEM CELLS article, researchers led by Tomas Barta (Masaryk University, Brno, Czech Republic) report that the miR‐183/96/182 cluster regulates PAX6 expression and its inhibition leads to increased neural retina expansion at early stages of differentiation of human retinal organoids derived from human pluripotent stem cells. Peskova et al. provide evidence that the miR‐183/96/182 cluster plays a significant role in the morphogenesis of the neural retina.