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OSKM Selectively Target Leukemia

The four transcription factors that make up the Yamanaka “cocktail” (Oct4, Sox2, Klf4, and Myc, or OSKM) are well known for their capacity to reprogram somatic cells into induced pluripotent stem cells (iPSCs). Now, Huafeng Xie and Thomas Graf discuss a recent paper from Wang et al. in Nature Communications that describes the unexpected discovery that short‐term activation of OSKM expression in acute myeloid leukemia cells in vivo induces apoptosis while negligibly affecting normal hematopoietic stem and progenitor cells. Head over to STEM CELLS to discover the potential implications of these findings for novel anti‐cancer strategies.