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Nucleoporins and the Epigenetic Regulation of NSCs

While adult neurogenesis supports brain function by providing new neurons for tissue homeostasis and memory processes, decreased neurogenesis occurs during aging and neurodegenerative diseases, thus reducing brain repair capacity. A greater understanding of the mechanisms implicated in neural stem cell (NSC) biology could increase the regenerative potential of NSC-based therapeutics. Now, a new STEM CELLS article from Claudia Colussi and Claudio Grassi (Istituto di Analisi dei Sistemi ed Informatica "Antonio Ruberti," Rome, Italy) discusses the emerging role of nuclear pore proteins as novel molecules that control stemness and fate specification of NSCs in the developing embryo and adult brain via epigenetic mechanisms.