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NSC Therapy for Perinatal Brain Injury

The limited treatment options for perinatal brain injury and the associated life-long burden provide the impetus driving the development of novel neuroregenerative therapies. Now, a new STEM CELLS Translational Medicine article from researchers led by Megan Finch-Edmondson (University of Sydney, Sydney, New South Wales) and Courtney A. McDonald (Hudson Institute of Medical Research, Clayton, Victoria, Australia) critically review those studies employing neural stem cell (NSC)-based therapies for perinatal brain injuries. Smith et al. also discuss the critical future research required for the clinical translation of NSC therapy for perinatal brain injury, including large animal studies, investigations into the need for neonatal immunosuppression, and the standardization of clinically-relevant behavioral outcomes.