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Novel Role for Thrombopoietin In HSPC Homing

A new study led by Hengxiang Wang (Medical Center of Air Forces), Yanhua Li (Beijing Institute of Radiation Medicine), and Xuetao Pei (Institute of Health Service and Transfusion Medicine, Beijing, China) describes a novel function of recombinant human thrombopoietin (TPO) in increasing hematopoietic stem and progenitor cell (HSPC) homing to the bone marrow, which subsequently results in enhanced long‐term engraftment of HSPCs in mice. Liu and Ding et al. found that TPO administration to patients followed by HSPCs transplantation improved platelet engraftment outcomes, especially in patients with severe aplastic anemia. This new STEM CELLS Translational Medicine study may represent a valuable and rapid means to improve both HSPC homing to the bone marrow and hematopoietic repopulation efficiency in patients.