You are hereJune 5, 2019
Novel Approaches to Achieve Thymic Regeneration
Exciting new research from the laboratory of Marita Bosticardo (IRCCS San Raffaele Scientific Institute, Milan, Italy) provides proof‐of‐principle for a new approach toward thymic regeneration. Bortolomai et al. generated thymic organoids by seeding gene‐modified postnatal murine thymic epithelial cells (TECs) into three‐dimensional (3D) collagen type I scaffolds mimicking the thymic ultrastructure. The in vivo results found that thymic organoids transplanted subcutaneously in athymic nude mice became vascularized but ultimately failed to support thymopoiesis because of limited persistence in vivo. See STEM CELLS Translational Medicine now for what could represent a launching off point for the development of new thymic regeneration strategies.